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| PUBLICATIONS |
| 2006 Khor, T.O., Keum, Y.-S., Lin, W., Kim, J.H., Hu, R., Shen, G., Gopalkrishnan, A., Reddy, B., Zheng, X., Conney, A., and Kong, A.-N.T. Combined inhibitory Effects of Curcumin and Phenethyl isothiocyanate (PEITC) on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice. Cancer Res. Jan 15;66(2):613-621, 2006 (Priority Report). [This manuscript has received quite a lot of media attention]. Shen, G., Xu, C., Hu, R., Jain, M.R., Nair, S., Lin, W., Yang, C.S., Chan, J.Y., and Kong, A.-N.T. Modulation of Nrf2-mediated gene expression by cancer chemopreventive agent curcumin in C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Mol. Cancer Ther. 5: 39-51, 2006. Jeong, S.-S., Jun, M. and Kong, A.-N.T. Nrf2: A potential molecular target for cancer chemoprevention by natural compounds. Antioxidants and Redox Signalling (Invited Review) Jan-Feb;8(1-2):99-106, 2006. Hu, R., Xu, C., Shen, G., Jain, M.R., Khor, T.O., Gopalkrishnan, A., Lin, W., Reddy, B., Chan, J.Y., and Kong, A.-N.T. Gene Expression Profiles Induced by Cancer Chemopreventive Isothiocyanate Sulforaphane in the Liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Let. Nov 18;243(2):170-92. Epub 2006 Mar 3. Reddy, B.S., Wang, X.X., Steele, V., Kopelovich, L., Kong, A.-N.T., Khor, T.O., Zheng, X., and Rao, C.V. Prevention of colon cancer by combination of low doses of atorvastatin, aspirin and celecoxib in F 334 rats. Cancer Research Apr 15;66(8):4542-6. Hu, R., Khor, T.O., Shen, G., Jeong, W.-S., Hebbar, V., Chen, C., Xu, C., Reddy, B., Chada, K. and Kong, A.-N.T. Cancer chemoprevention of intestinal polysis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis Oct;27(10):2038-46, 2006. Epub 2006 May 4. [This manuscript has received quite a bit of media attention]. Yuan, X., Xu, C., Pan, Z., Keum, Y.-S., Kim, J.-H., Shen, G., Yu, S., Khor, T.O., Ma, J., and Kong, A.-N.T. Butylated Hydroxyanisole Regulates ARE-mediated Gene Expression via Nrf2 Coupled with ERK and JNK Signaling Pathway in HepG2 cells. Mol. Carcinog. Nov;45(11):841-50, 2006 [Epub ahead of print May 31, 2006]. Zheng, X., Chang, R.L., Cui, X.-X., Avila, G.E., Hebbar, V., Gazotto, M., Shih, W.J., Lin, Y., Lu, S.-E., Rabson, A.B., Kong, A.-N.T. , and Conney, A.H. Effects of 12-O-tetradecanoylphorbol-12-acetate (TPA) in combination with paclitaxel (Taxol) on prostate cancer LNCaP cells cultured in vitro or grown as xenografts tumors in immunodeficient mice. Clin. Cancer Res. Jun 1;12(11 Pt 1):3444-51, 2006. Lin, W., Shen, G., Yuan, X., Jain, M.R, Yu, S., Zhang, A., Chen, J.D., and Kong, A.-N.T. Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators. J. Biochem. Mol. Biol. May 31;39(3):304-10. 2006. Mandlekar, S., Hong, J.L., and Kong, A.-N.T. Modulation of metabolic enzymes by dietary phytochemicals: A review of mechanisms underlying beneficial versus unfavorable effects (Invited review). Current Drug Metabolism 7: 661-675, 2006. Xu, C., Huang, M.-T., Shen, G., Yuan, X., Lin, W., Khor, T.O., Conney, A.H., and Kong, A.-N.T. Inhibition of 7,12-dimethylbenz[a]anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by Nrf2. Cancer Res. 66(16):8293-8296, Aug 15, 2006. Xu, C., Yuan, X., Pan, Z., Shen, G., Kim, J.-H., Yu, S., Khor, T.O., Li, W., Ma., J., and Kong, A.-N.T. Mechanism of action of isothiocyanates: The induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Mol. Cancer Ther. Aug;5(8):1918-26, 2006. Keum, Y.-S., Chang, P.P.-J., Nair, S., Kim, J.-H., Han, J.H., and Kong, A.-N.T. p38 MAPK Isoforms Phosphorylate Nrf2 and Negatively Regulate the Antioxidant-Responsive Element (ARE) Contributing to the Induction of Hemoxygenase-1 (HO-1). Cancer Research Sep 1;66(17):8804-13, 2006. Gopalakrishnan, A., Xu, C., Nair, S.S., Chen, C., Hebbar, V., and Kong, A.-N.T. Modulation of Activator Protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC-3 cells. Arch Pharm Res. Aug;29(8):633-44, 2006. Li, W., Yu, S.-W., Yuan, X.-L., and Kong, A.-N.T. Nrf2 possesses a redox-sensitive NES in the Neh5 transactivation domain. J. Biol. Chem. Sep 15;281(37):27251-63, 2006. [Epub 2006 Jun 21]. Khor, T.O., Hu, R., Shen, G., Jeong, W.S., Hebbar, V., Chen, C., Xu, C., Reddy, B., Chada, C., and Kong, A.N.T. Pharmacogenomics of Cancer Chemopreventive Isothiocyanate Compound Sulforaphane in the Intestinal Polyps of ApcMin/+ Mice. Biopharm. Drug Disposition. Sep 4;27(9):407-420 [Epub ahead of print]. Hu, R., Xu, C., Shen, G., Jain, M.R., Khor, T.O., Gopalkrishnan, A., Lin, W., Reddy, B., Chan, J.Y., and Kong, A.-N.T. Identification of Nrf2-regulated genes Induced by Chemopreventive Isothiocyanate PEITC Using Nrf2 Knock-out mice. Life Sciences Oct 12;79(20):1944-55. Epub 2006 Jun 20. 2006. Khor, T.O. Ibrahim, S. and Kong, A.-N.T. Toxicogenomics in drug discovery and drug development: Potential applications and future challenges (Invited Expert Review). Pharmaceutical Research Aug;23(8):1659-64. 2006 [Epub ahead of print; July 21, 2006]. Hu, R., Shen, G., Yerramilli, U.R., Lin, W., Xu, C., Nair, S., and Kong, A.-N.T. In vivo Pharmacokinetics, Activation of MAPK and Regulation of Gene Expression Elicited by Cancer Chemopreventive compound BHA in the Mice. Archives Pharm. Res. Oct;29(10):911-20, 2006. Nair, S., Xu, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., Jain, M.R., Lin, W., Keum, Y.S., Liew, C., Chan, J.Y., and Kong, A.N.T. Pharmacogenomics of Phenolic Antioxidant Butylated Hydroxyanisole (BHA) in the Small Intestine and Liver of Nrf2 Knockout and C57BL/6J Mice. Pharm. Res. Nov;23(11):2621-37, 2006. [Epub 2006 Sep 13]. Keum, Y.S., Han, Y.H., Liew, C., Kim, J.H., Xu, C., Yuan, X., Shakarjian, M.P., Chong, S., and Kong, A.N.T. Induction of Heme Oxygenase-1 (HO-1) and NAD[P]H: Quinone Oxidoreductase 1 (NQO1) by a Phenolic Antioxidant, Butylated Hydroxyanisole (BHA) and Its Metabolite, tert-Butylhydroquinone (tBHQ) in Primary-Cultured Human and Rat Hepatocytes. Pharm. Res. Nov;23(11):2586-94, 2006 [Epub 2006 Oct 18]. Khor, T.O., Huang, M.T., Kwon, K.H., Chan, J.Y., Reddy, B.S. and Kong, A.N.T. Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis. Cancer Research 66:11580-11584, December 15 2006 (Priority Report). Nair, S., Xu, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., Jain, M.R., Liew, C., Chan, J.Y., and Kong, A.N.T. Toxicogenomics of Endoplasmic reticum stress inducer tunicamycin in the small intestine and liver of Nrf2 Knockout and C57BL/6J Mice. Toxicol. Lett. 168:21-39, 2007 [Epub Nov 10, 2006]. 2005 Jeong, W.-S., Keum, Y.-S., Chen, C., Jain, M.R., Shen, G., Li, W., Kim, J.-H., and Kong, A.-N.T. Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. J. Biochem. Mol. Biol. 38: 167-176, March 31, 2005. Xu, C.-J., Li, C.Y.-T., and Kong, A.-N.T. Induction of Phase I, II and III Drug Metabolism/Transport by Xenobiotics. Arch. Pharmacal Res. 28: 249-268, March 2005 (Invited Review). Hebbar, V., Shen, G., Hu, R., Kim, B.-R., Chen, C., Korytko, P.J., Crowell, J.A., Levine, B.F. and Kong, A.-N.T. Toxicogenomics of resveratrol in rat liver. Life Sciences 76: 2299-2314, April 2005 (Available online January 29, 2005). Xu, C.-J., Shen, G., Chen, C., Genlinas, C., and Kong, A.-N.T. Suppression of NF-kB and NF-kB-regulated Gene Expression by sulforaphane and PEITC through IkBa, IKK pathway in human Prostate PC-3 cells. Oncogene Jun 30;24(28):4486-95, 2005 (available online March 18, 2005). Chen, C. and Kong, A.-N.T. Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects (Invited Review). Trends in Pharmacol. Sci. June; 26(6):318-326, 2005 (Available online 6 May 2005). Li, W., Jain, M.R., Chen, C., Yue, X., Hebbar, V., Zhou, R. and Kong, A.-N.T. NRF2 possesses a Redox-insensitive nuclear export signal overlapping with the leucine zipper motif. J. Biol. Chem. Aug 5;280(31):28430-8. 2005. [Epub ahead of print May 23, 2005]. Shen, G., Xu, C., Hu, R., Jain, M.R., Nair, S., Lin, W., Yang, C.S., Chan, J.Y., and Kong, A.-N.T. Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Pharmaceutical Research, 22(11): 1805-20, November 2005. [Epub August 16, 2005]. Shen, G., Xu, C., Chen, C., Hebbar, V., and Kong, A.-N.T. p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. Cancer Chemother. Pharmacol. Feb;57(3):317-27, 2006. [Epub 2005 Sep 17]. Xu, C., Shen, G., Yuan, X., Nair, S., Kim, J.H., Gopalkrishnan, A., and Kong, A.-N.T. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by isothiocyanates in PC-3 cells. Carcinogenesis Mar;27(3):437-45, 2006. [Epub 2005 Nov 4]. Keum, Y.-S., Jeong, W.-S., and Kong, A.-N.T. Chemopreventive functions of isothiocyanates. Drugs News Perspectives (Invited Review). 18: No. 7, September, 445-451, 2005. Kim, J.H., Xu, C., Shen, G., Keum, Y.-S., Reddy, B., Conney, A., and Kong, A.-N.T. Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-Phenylethyl isothiocyanate and Curcumin. Carcinogenesis Mar;27(3):475-82, 2006. [Epub 2005 Nov 19]. Shen, G., Jeong, W.-S., Hu, R., and Kong, A.-N.T. Regulation of Nrf2, AP-1 and NF-kB signaling pathways by chemopreventive agents. Antioxidants and Redox Signalling Nov-Dec;7(11-12):1648-63. 2005 (Invited Review). 2004 Jeong, W.-S., Kim, I.-W., Hu, R., and Kong, A.-N.T. Modulation of AP-1 by natural chemopreventive compounds in human HT-29 cancer cell line. Pharmaceutical Research 21: 649-660, April 2004. Jeong, W.-S., Kim, I.-W., Hu, R., and Kong, A.-N.T. Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharmaceutical Research 21: 661-670, April 2004. Hu, R., Hebbar, V., Kim, B.R., Chen, C., Winnik, B., Buckley, B., Soteropoulos, P., Tolias, P., Hart, R.P., and Kong, A.-N.T. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J. Pharmacol. Exp. Ther. July; 310 (1): 263-71, 2004. (Feb 26, 2004 – Epub ahead of print). Shen, G., Hebbar, V., Nair, S., Xu, C., Li, W., Lin, W., Keum, Y.-S., Han, J., Gallo, MA and Kong, A.-N.T. Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein. J. Biol. Chem. May 28; 279: 23052-60, 2004 (Epub March 13, 2004). Chen, C., and Kong, A.-N.T. Dietary chemopreventive compounds and EpRE signaling (Invited review). Free Radical Biology and Medicine, June 15; 36: 1505-16, 2004. Chen, C., Pung, D., Leong, V., Hebbar, V., Shen, G., Nair, S., Li, W., and Kong, A.-N.T. Induction of detoxifying enzymes by garlic organosulfur compounds: Role of Nrf2, chemical structure and stress signals. Free Radical Biology and Medicine, 37: Issue 10, November 15, 1578-1590, 2004 (Available online August 13, 2004). Kong, A.-N.T. Signal transduction in cancer chemoprevention. Mutation Research 555: Issue 1-2, November 2, 1-2, 2004 (Editorial). Keum, Y. Jeong, W.-S., and Kong, A.-N.T. Chemoprevention by isothiocyanates and their underlying molecular mechanisms. Mutation Research 555: Issue 1-2, November 2, 191-202, 2004 (Invited Review). 2003 Kim, B.-R., Hu, R., Keum, Y.-S., Hebbar, V., Shen, G. and Kong, A.-N.T. Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Research 63: 7520-7525, 2003. Keum, Y., Owuor, E.D., Kim, B.-R., Hu, R. and Kong, A.-N.T. Involvement of Nrf2 and JNK in the activation of antioxidant responsive element (ARE) by phenethyl isothiocyanate (PEITC) chemopreventive agent. Pharmaceutical Research 20: 1351-1356, 2003. Chen, C., Shen, G., Hebbar, V., Hu, R., Owuor, E.D., and Kong, A.-N.T. Epigallocatechin-3-gallate-induced stress signals in HT-29 human colon adenocarcinoma cells. Carcinogenesis 24:1369-1378, 2003. Hu, R., Chen, C., Kim, B.R., and Kong, A.-N.T. The roles of JNK and apoptotic signaling pathways in PEITC-mediated pharmacodynamics responses in human HT-29 colon cancer cells. Carcinogenesis 24: 1361-1367, 2003. Jiang, Z., Chen, C., Yang, B., Hebbar, V., and Kong, A.-N.T. Induction of Phase II Drug Metabolizing Enzymes by Xenobiotics in Seven Mammalian Cell Lines. Life Sciences 72(20): 2243-2253, 2003. 2002 Chen, Y.-R., Han, J., Kori, R., Kong, A.-N.T. and Tan, T.-H. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J. Biol. Chem. 277:39334-39342, 2002. Misra, P., Owuor, E.D., Li, W., Yu, S., Qi, C., Meyer, K., Zhu, Y.-J., Rao, M.S., Kong, A.-N.T. and Reddy, J.K. Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of Transcriptional Regulation by Mitogen-activated Protein Kinase. J. Biol. Chem. 277(50):48745-54, Dec 13; 2002. Rushmore, T.H. and Kong, A.-N.T. Pharmacogenomics, Regulation and Signaling Pathways for Phase I and II Drug Metabolizing Enzymes (Invited Review) Current Drug Metabolism 3: 481-490, 2002. Owour, E. and Kong, A.-N.T. Antioxidants and Oxidants Regulated Signal Transduction Pathways (Invited Review). Biochemical Pharmacology 64: 765-770, 2002. 2001 Mandlekar, S., and Kong, A.-N.T. Mechanisms of tamoxifen-induced apoptosis. Apoptosis 6: 469-477, 2001. Yu, R., Hebbar, V., Kim, D., Mandlekar, S., Pezzuto, J., and Kong, A.-N.T. Resveratrol inhibits phorbol ester and UV-induced AP-1 activation by interfering with tyrosine kinase and mitogen-activated protein kinase pathways. Molecular Pharmacology 61: 217-224, 2001. Kong, A.-N.T., Owour, E., Yu, R., Hebbar, V., Chen, C., Hu, R., and Mandlekar, S. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metabolism Reviews 33: 255-271, 2001. Kong, A.-N.T., Yu, R., Owour, E., Hebbar, V., Chen, C., Hu, R., Ee, R. and Mandlekar, S. Signal transduction events elicited by cancer prevention compounds. (Invited review). Mutation Research 480-481: 231-241, 2001. 2000 Mandlekar, S., Hebbar, V., Christov, K., and Kong, A.-N.T. Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: Activation of caspases and induction of apoptosis in rat mammary carcinoma and in human breast cancer cell lines. Cancer Res., December 1, 60: 6601-6606, 2000. Mandlekar, S., Yu, R., Tan, T.-H., and Kong, A.-N.T. Activation of caspase-3 and c-Jun N-terminal kinase-1 (JNK1) signaling pathways in tamoxifen-induced apoptosis in human breast cancer cells. Cancer Res., November 1, 60:5995-6000, 2000. Yu, R., Chen, C., Mo, Y., Hebbar, V., Owour, E.D., and Kong, A.-N.T. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via Nrf2-dependent mechanim. J. Biol. Chem., 275: December 22, 39907-39913, 2000 (in press ¡V September 13, 2000). Yu, R., Mandlekar, S., and Kong, A.-N.T. Molecular mechanisms of butylated hydroxylanisol-induced toxicity: Induction of apoptosis through direct release of cytochrome c. Mol. Pharmacol., 58: 431-437, 2000. Yu, R., Mandlekar, S., Ruben, S., Ni, J., and Kong, A.-N.T. TRAIL-mediated apoptosis in androgen-independent prostate cancer cells. Cancer Res., 60: 2384-2389, 2000. Yu, R., Mandlekar, S., Tan, T.-H., and Kong, A.-N.T. Protein kinase C-independent activation of c-Jun N-terminal kinase, p38, and apoptosis by chelerythine. J. Biol. Chem., 275: 9612-9619, March 31, 2000. Kong, A.-N.T., Yu, R., Chen, C., Mandlekar, S., and Primiano, T. Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch. Pharm. Res., 23: 1-16, 2000 (Invited Review). Yu, R., Mandlekar, S., Lei, W., Tan, T.-H., and Kong, A.-N.T. p38 mitogen-activated protein kinase negatively regulates antioxidant response element-mediated gene expression. J. Biol. Chem., 275: 2322-2327, Jan 28, 2000. 1999 Yu, R., Lei, W., Mandlekar, S., Weber, M.J., Der, C.J., Wu, J., and Kong, A.-N.T. Role of a mitogen-activated protein kinase pathway in the induction of Phase II detoxifying enzymes by chemicals. J. Biol. Chem., 274: 27545-27561, 1999. Kong, A.-N.T., Mandlekar, S., Yu, R., Lei, W., and Fasanmade, A. Pharmacodynamics and toxicodynamics of drug action: Signaling in cell survival and cell death. Pharm. Res., 16: 790-798, 1999 (Review). 1998 and Earlier Yu, R., Mandlekar, S., Harvey, K.J., Ucker, D.S. and Kong, A.-N.T. Chemopreventive Isothiocyanates Induce Apoptosis and Caspase-3-Like Protease Activity. Cancer Res., 58: 402-408, 1998. Lei,W., Yu, R., Mandlekar, S. and Kong, A.-N.T. Induction of apoptosis and activation of ICE/Ced-3 protease (caspase 3) and c-jun N-terminal kinases 1 by benzo[a]pyrene. Cancer Res., 58: 2102-2106, 1998. Yu, R., Tan, T.-H, and Kong, A.-N.T. Phenolic antioxidants, butylated hydroxyanisole (BHA) and its metabolite tert-butylhydroquinone (BHQ) differentially regulate mitogen-activated protein kinases. J. Biol. Chem., 272: 28962-70, 1997. Yu, R., Jiao J., Duh, J.-L., Tan, T.-H., and Kong, A.-N.T. Activation of mitogen-activated protein kinases by green tea polyphenols: potential signaling pathways in the regulation of antioxidant-responsive element-mediated phase II enzyme gene expression. Carcinogenesis, 18: 451-456, 1997. Yu, R., Jiao J., Duh, J.-L., Tan, T.-H., and Kong, A.-N.T. Phenethyl isothiocyanate, A natural chemopreventive agent, activates c-jun N-terminal kinase 1 (JNK1). Cancer Res., 56: 2954-2959, 1996. Hellriegel, E.T., Matwyshyn, G.A., Fei, P., Dragnev, K.H., Nims, R.W., Lubet, R.A., and Kong, A.-N.T. Regulation of phase I and phase II detoxifying enzymes sulfotransferases and UDP-glucuronosyltransferases gene expression by tamoxifen in rat liver. Biochem. Pharmacol., 52: 1561-1568, 1996. Fei, P., Matwyshyn, G.A., Rushmore, T.H., and Kong, A.-N.T. Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents. Pharm. Res., 13: 1043-1048, (1996). Kong, A.-N.T., Fei, P., and Wong, B.K. Differential expression of phenol family of of UDP-glucuronosyltransferases in hepatoma cell lines. Pharm. Res., 12: 309-312, 1995. Kong, A.-N.T., Tamasko, L., Waldman, S., Osborne, B., Deutsch, P., Goldberg, M., and Bjornsson, T.D. Losartan does not affect the pharmacokinetics and pharmacodynamics of warfarin. J. Clin. Pharmacol., 35:1008-1015, 1995. Kong, A.-N.T., and Fei, P. Molecular cloning of three sulfotransferase cDNAs from mouse liver. (2nd International Workshop on the Sulfation of Xenobiotics and Endogenous Compounds, June 3-6, 1993, Ardmore, OK) Chemico-Biological Interactions, 92:161-168, 1994. Kong, A.-N.T., Ma, M., Tao, D., and Yang, L. Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (ugtBr/p). Pharm. Res., 10: 461-465, 1993. Kong, A.-N.T., Yang, L., Ma, M., Tao, D., and Bjornsson, T.D. Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver. Biochem. Biophys. Res. Commun., 187: 448-454, 1992. Wange, R.L., Kong, A.-N.T. and Samelson, L.E. A Tyrosine-Phosphorylated 70 kDa Protein Binds a Photoaffinity Analogue of ATP and Associates with Both the Zeta Chain and CD3 Components of the Activated T Cell Antigen Receptor. J. Biol. Chem., 267: 11685-11688, 1992. Petersen, D.D., Kong, A.-N.T., Jorge, L.F., Nebert, D.W. and Arias, T.D. Debrisoquine polymorphism: Novel CYP2D6 gene BamHI RFLP in the Ngawbe Guaymi Indian of Panama. Pharmacogenetics, 1: 136-142, 1991. Kong, A.-N. and Jusko, W.J. Disposition of methylprednisolone and its sodium succinate prodrug in vivo and in perfused liver of rats: Nonlinear and Sequential First-Pass Metabolism. J. Pharm. Sci., 80: 409-415, 1991. Kong, A.-N., Ludwig, E., Slaughter, R., DiStefano, P., DeMasi, J., Middleton, E. and Jusko, W.J. Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in man. Clin. Pharmacol. Ther., 46: 616-628, 1989. Kong, A.-N. and Jusko, W.J. Definitions and applications of mean transit/residence time to a two-compartment mammillary plasma clearance model. J. Pharm. Sci., 43: 157-165, 1988. |
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